Aminoglycosides

(Gentamicin, Kanamicin, Amikacin, Streptomycin, Neomycin)

Class: Bacteriocidal, Broad Spectrum

Mechansim: Irreversibly bind to the 30S ribosome

Indications: Infections caused by susceptible pathogens, pneuomonias, urinary tract infections, endometritis, and septicemias that are resistant to other antibiotics.

Antagonists: Amphotericin B, Cephalosporins produce nephrotoxicity.

Side effects: Intestinal flora may be disrupted, diarrhea may occur. Other includes intramuscular blockage (when used with anaesthetic agents), nephrotoxicity and ototoxicity (oto=ear)

Notes: These are used in all species

1.  Gentamycin

Horses: 3-6mg/kg BID IM                                Ruminants: 3-6mg/kg BID IM

Trade name	Composition	Packing	Company
Genton	100 mg/ml	50 & 100 ml	ICI
Gentasel – 10	100 mg/ml	50 & 100 ml	Selmore PH
Medi G 10	100 mg/ml	50 & 100 ml	Medivet
Gentasal 100	100 mg/ml	50 & 100 ml	Atzan
Gentafar	100 mg/ml	50 & 100 ml	Farvet
Gentawan – 10	100 mg/ml	100ml	Nawan
Gentalin – 10	100 mg/ml	50,100ml	Star
Gentasal – 50	50 mg/ml	100 ml	Atzan

2.  Gentamycin + Trimethoprim + Sulfonamide

Trade name	Composition	Packing	Company	Recommended Dose
Genta plus	30+125+25 mg/ml	50,100ml	Leads Ph.	First Dose=30ml/50kg 2nd Dose=15ml/50kg

3. Tylosin + Gentamycin

Trade name	Composition	Packing	Company	Recommended Dose
Tylogent	100 + 50 mg/ml	50, 100ml	Eterna	LA=1ml/30kg SA=1ml/20kg

4. Kanamycin

Notes: More good effects in Dogs & cats. Excessive dose can effect in 8^th Cranial Nerve.

Horses: 12-15mg/kg IM                                    Ruminants: 12-15 mg/kg IM

Trade name	Composition	Packing	Company
Kanasym	100 mg/ml	50,100ml	Symans
Kanacon	100 mg/ml	50,100ml	Vetcon Ph.
Kana Kak	100 mg/ml	50 ml	Trust Pharma
Kanamycin	100mg/ml	10, 50ml	China
Kanachron	100 mg/ml	10 & 50 ml	Star

5.  Kanmycine + Ampicillin + Prednisolone + Chlorpheniramine

Trade name	Composition	Packing	Company	Recommended Dose
Kapcine	100mg+200mg+10mg+4mg	50, 100ml	Leads Ph.	LA=1ml/20kg SA=1ml/10kg

For Pharmacology Watch the following Video