Table of Contents
(Chloramphenicol, Florfenicol)
Class: Bacteriostatic, Broad Spectrum
Mechanism: Bind to the 50S ribosome
Indications: Upper respiratory tract infections, urinary tract infections, enteritis, and bacterial conjunctivitis. Side effects: Cause multiple genetic effects i.e. Aplastic anaemia, Bone marrow dysfunction, blood dyscrasias (imbalance of four body fluids i.e. blood, bile, lymph and phlegm).
Notes: Amphenicol are very stable and should not be used in food-producing animals because residues remain secreted upto 28 days in meat, milk or eggs. They are getting banned for producing genetic effects.
1. Chloramphenicol
| Horses: 50mg/kg IV for 4 hrs | Ruminants: Don’t used in food produing animals |
| Trade name | Composition | Packing | Company | Recommended Dose |
| Chlorocare | 20 mg/ml | 50 ml | Vetycare | Ls= 25 ml Ms= 10 ml Ss= 3 ml |
| Rexaphenicol | 20 mg/ml | 50 ml | SJ & G | Same as above |
| Chloramphenicol 20 | 20 mg/ml | 100 ml | Bremer | Same as above |
| Chlorobiotic | 20 mg/ml | 50 ml | Star | Same as above |
2. Oxytetracycline + Chloramphenicol + Prednisolone + Lidocaine
Notes:Antimicrobial as well as anti-inflammatory effect.
| Trade name | Composition | Packing | Company | Recommended Dose |
| Chlorotatrason | 5 g + 10 g + 500 mg + 1 g | 50 ml | Marial | 1 ml/10 kg |
| Oxyclore-P | 5 g + 10 g + 500 mg + 1 g | 50 ml | Enterna | 1 ml/10 kg |
| Oxypenisol | 5 g + 10 g + 500 mg + 1 g | 50 ml | Star | 1 ml/10 kg |
3. Florfenicol
Notes: Should not be used in calves and Heifers. Approved for P.hemolytica and P.multocida
Horses: Don’t Used Ruminants: 20mg/kg IM repeated after 48 Hrs
| Trade name | Composition | Packing | Company | Recommended Dose |
| Naflor | 300 mg/ml | 10 & 50 ml | Nawan | 1 ml/15 kg |
| Florofen | 300 mg/ml | 50 ml | Leads | 1 ml/15 kg |