AMPHENICOLS

(Chloramphenicol, Florfenicol)

Class: Bacteriostatic, Broad Spectrum

Mechanism: Bind to the 50S ribosome

Indications: Upper respiratory tract infections, urinary tract infections, enteritis, and bacterial conjunctivitis. Side effects: Cause multiple genetic effects i.e. Aplastic anaemia, Bone marrow dysfunction, blood dyscrasias (imbalance of four body fluids i.e. blood, bile, lymph and phlegm).

Notes: Amphenicol are very stable and should not be used in food-producing animals because residues remain secreted upto 28 days in meat, milk or eggs. They are getting banned for producing genetic effects.

1.  Chloramphenicol

Horses: 50mg/kg IV for 4 hrs Ruminants: Don’t used in food produing
animals
Trade name Composition Packing Company Recommended Dose
Chlorocare 20 mg/ml 50 ml Vetycare Ls= 25 ml Ms= 10 ml Ss= 3 ml
Rexaphenicol 20 mg/ml 50 ml SJ & G Same as above
Chloramphenicol 20 20 mg/ml 100 ml Bremer Same as above
Chlorobiotic 20 mg/ml 50 ml Star Same as above

2. Oxytetracycline + Chloramphenicol + Prednisolone + Lidocaine

Notes:Antimicrobial as well as anti-inflammatory effect.

Trade name Composition Packing Company Recommended Dose
Chlorotatrason 5 g + 10 g + 500 mg + 1 g 50 ml Marial 1 ml/10 kg
Oxyclore-P 5 g + 10 g + 500 mg + 1 g 50 ml Enterna 1 ml/10 kg
Oxypenisol 5 g + 10 g + 500 mg + 1 g 50 ml Star 1 ml/10 kg

3.  Florfenicol

Notes: Should not be used in calves and Heifers. Approved for P.hemolytica and P.multocida

Horses: Don’t Used Ruminants: 20mg/kg IM repeated after 48 Hrs

Trade name Composition Packing Company Recommended Dose
Naflor 300 mg/ml 10 & 50 ml Nawan 1 ml/15 kg
Florofen 300 mg/ml 50 ml Leads 1 ml/15 kg

Video

Mechanism of Action

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