Farm Animals

AMPHENICOLS

(Chloramphenicol, Florfenicol) Class: Bacteriostatic, Broad Spectrum Mechanism: Bind to the 50S ribosome Indications: Upper respiratory tract infections, urinary tract infections, enteritis, and bacterial conjunctivitis. Side effects: Cause multiple genetic effects i.e. Aplastic anaemia, Bone marrow dysfunction, blood dyscrasias (imbalance of four body fluids i.e. blood, bile, lymph and phlegm). Notes: Amphenicol are very stable and …

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Tetracyclines

(Oxytetracycline, Doxycycline) Class: Bacteriostatic, Broad Spectrum Mechanism: Reversibly bind to the 30S ribosome Indications: Infections caused by tetracycline-sensitive strains; anaplasmosis, often ineffective for endocarditis, empyema, meningitis, septic arthritis and osteomyelitis. Antagonists: Antacids, milk, diuretics, methoxyflurane, penicillins, ferrous sulfate. Side effects: Causes nephrotoxicity when administered at high Recommended Doses, Calcium Chelation is the major side effect. …

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Aminoglycosides

(Gentamicin, Kanamicin, Amikacin, Streptomycin, Neomycin) Class: Bacteriocidal, Broad Spectrum Mechansim: Irreversibly bind to the 30S ribosome Indications: Infections caused by susceptible pathogens, pneuomonias, urinary tract infections, endometritis, and septicemias that are resistant to other antibiotics. Antagonists: Amphotericin B, Cephalosporins produce nephrotoxicity. Side effects: Intestinal flora may be disrupted, diarrhea may occur. Other includes intramuscular blockage …

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Cephalosporins

Class: Bactericidal, Differ in Generations Mechanism: Cell wall inhibition Indications: Very effective for respiratory diseases, Skin diseases and most of bacteria including beta-lactamase producing strains. Also used in Urinary Tract infections, Soft tissues and Bones. Antagonists: Gentamycin Precaution: Doses should be reduced in liver affected animals. Poorly absorbed from GIT. Notes: First generation has strongest …

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macrolides

MACROLIDES

(Tylosin, Erythromycin,Tilmicosin) Class: Bacteriostatic, Narrow Spectrum Mechanism: Binding to the 50S ribosomal RNA and inhibit translocation of the peptidyl tRNA Indications: URT infections, mastitis, metritis, and foot rot caused by microorganism susceptible to macrolides. Side effects: Include diarrhea, vomiting and anorexia in small animals after oral administration. IM injection is painful. Notes: Can’t be used …

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Broad Spectrum Pencillins

1. Amoxicillin Indications: Good Results in GIT and Skin diseases. Antagonist: Tetracyclines, Chloramphenicol, Erythromycin, and Cephaloridine. Notes: From GI tract absorbed better than ampicillin Horses: 11-22mg/kg IM Bid                                            Ruminants: 11-22mg/kg IM Bid Trade name Composition Packing Company Clamoxyl LA 15% 150 mg/ml 50 & 100 ml Pfizer Farmox LA 150 mg/ml 50 & 100 ml …

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ANTIBIOTICS

A) Pencillins Class: Bactericidal Mechanism: Cell wall inhibition Indications: infections caused by any Gram Positive Bacteria and penicillin sensitive organism: Skin Infections, Bacterial pneumonia, URT, Strangles, Blackleg and Urinary tract infections (at higher Doses). Synergism: Aminoglycosides Antagonists: Tetracyclines, Chloramphenicol and Paromomycin. Notes: It can cause Allergy, vomiting, diarrhea (or Enteritis if administered orally). Adrenaline must …

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