cephalosporins by thevetscare

Cephalosporins

cephalosporins by thevetscare
cephalosporins by thevetscare

Class: Bactericidal, Differ in Generations

Mechanism: Cell wall inhibition

Indications: Very effective for respiratory diseases, Skin diseases and most of bacteria including beta-lactamase producing strains. Also used in Urinary Tract infections, Soft tissues and Bones.

Antagonists: Gentamycin

Precaution: Doses should be reduced in liver affected animals. Poorly absorbed from GIT.

Notes: First generation has strongest response against G+ve Cocci, Proteus, E.coli, Klebsiella than other generations. While 3rd Generation has good response against G-ve Bacilli

First Generation

Narrow Spectrum only for G+ve

1.  Cephradine:

Trade name Composition Packing Company
Velosef 250mg/500mg/1gm: 5ml,10ml Bristol M.S.
Vericef susp. 250mg/500mg/1gm: 60ml,100ml Indus
  1. Cephalexin

Horses: 10-30 mg/kg, PO, TID- QID                             Ruminants: 7mg/kg IM Sid

Trade name Composition Packing Company
Ceporex inj 250mg/500mg 5ml, 10ml Indus
Keflex syp. 25 mg/ ml, 50mg/ ml 60ml Eli Lilly

Third generation

Broad Spectrum both for G+ve and G-ve

1.  Ceftiofur Hydochloride

Side effects: Usually safe to use in animals. However allergic reaction can occur. Rare bleeding disorders have been reported from cephalosporins.

Horses: 2.2-5 mg/kg IV IM              Ruminants: 1.1-2.2 mg/kg IM IV

Trade name Composition Packing Company
Excenel RTU 50 mg/ml 100 ml Pfizer
Cefur RTU 50 mg/ml 10, 50 & 100 ml Nawan

2.  Cefotaxime Sodium

Antagonists: Gentamycin

Side effects: Usually safe to use in animals. But allergic reactions, vomiting and diarrhea may occur in some animals.

Horses: 20-30 mg/kg IV   Ruminants: according to the weight of the animal

Trade name Composition Packing Company
Excef 250mg, 500mg,1gm 5ml, 10ml Indus
Ceforin 250mg,500mg,1gm 10ml, 5ml Nawan labs

3. Ceftriaxone Sodium

Horses: 25-50mg/kg IM

Trade name Composition Packing Company
Oxidil 250mg,500mg,1gm 5ml,10ml Sami
Maxaf 250mg,500mg,1gm 5ml,10ml Indus

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